Background: The aim of APACE (Advantageous Predictors of Acute Coronary Syndrome Evaluation Study) is to test if the use of meticulous patient history, digital and analogue ECG parameter and novel biomarkers (including novel, sensitive and high-sensitive cardiac troponin I and T, Copeptin, myeloperoxydase, Endothelin) can provide a faster detection or exclusion of acute myocardial infarction in patients presenting with acute chest pain to the emergency department. Trial Registration No: NCT00470587 (clinicaltrials.gov) Link Trial Status: Enrollment active (n>8000 patients since 2006), ongoing data analysis and publishing Enrolling Centers: Switzerland Worldwide: Cantonal Hospital Liestal Czech Republic: Brno University Hospital Basel Poland: Zabrze University Hospital Zürich Spain: Hospital Clinico San Carlos, Madrid Hospital Clinic, Barcelona Core Study Team: Important Publications: (click on links to see abstracts)
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Incremental value of copeptin for rapid rule out of acute myocardial infarction.Reichlin T, Hochholzer W, Stelzig C et al. J Am Coll Cardiol. 2009 Jun 30;54(1):60-8. Incremental value of high-sensitivity cardiac troponin T for risk prediction in patients with suspected acute myocardial infarction.Hochholzer W, Reichlin T, Twerenbold R et al. Clin Chem. 2011 Sep;57(9):1318-26. Early diagnosis of acute myocardial infarction in patients with pre-existing coronary artery disease using more sensitive cardiac troponin assays.Reiter M, Twerenbold R, Reichlin T et al. Eur Heart J. 2011 Oct 31. Early diagnosis of acute myocardial infarction in the elderly using more sensitive cardiac troponin assays.Reiter M, Twerenbold R, Reichlin T et al. Eur Heart J. 2011 Jun;32(11):1379-89. Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction.Reichlin T, Irfan A, Twerenbold R et al. Circulation. 2011 Jul 12;124(2):136-45. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays.Reichlin T, Hochholzer W, Bassetti S et al. N Engl J Med. 2009 Aug 27;361(9):858-67. Dr. M. Rubini Giménez Dr. Pedro Lopez MAPS MAPS Desiree Wussler Dr. Jasper Boeddinghaus Dr. Luca Koechlin Valentina Tröster Paul David Ratmann Ana Yufera Markus Riesterer