Background: PROVOCATION (Prophylactic Intravenous Hydration for Contrast Agent Toxicity Prevention Study) is a randomized, controlled, open-label, multi-center study evaluating the efficacy of two regimens of sodium bicarbonate compared with a prolonged infusion of sodium chloride in the prevention of contrast induced nephropathy. Trial Registration No: NCT00130598 (clinicaltrials.gov) Link Trial Status: Enrollment closed, manuscript published, ongoing data analysis Enrolling Centers : (click on images to enlarge) Core Study Team: Recent Publication: